The Kansas City metropolitan area is a bi-state metropolitan area anchored by Kansas City, Missouri. Its 14 counties straddle the border between the U.S. states of Missouri (9 counties) and Kansas (5 counties). With 8,472 square miles (21,940 km²) and a population of more than 2.2 million people, it is the second-largest metropolitan area centered in Missouri (after Greater St. Louis) and is the largest metropolitan area in Kansas, though Wichita is the largest metropolitan area centered in Kansas. Alongside Kansas City, Missouri, these are the suburbs with populations above 100,000: Overland Park, Kansas; Kansas City, Kansas; Olathe, Kansas; Independence, Missouri; and Lee's Summit, Missouri.

Business enterprises and employers include Cerner Corporation (the largest, with almost 10,000 local employees and about 20,000 global employees), AT&T, BNSF Railway, GEICO, Asurion, T-Mobile (formerly Sprint), Black & Veatch, AMC Theatres, Citigroup, Garmin, Hallmark Cards, Waddell & Reed, H&R Block, General Motors, Honeywell, a Ford Motor Company factory, The Kansas City Star, Bayer, Children's Mercy Hospital, Truman Medical Center-Hospital Hill, and Andrews McMeel Universal (representing Garfield, Calvin and Hobbes, and Doonesbury). Shopping centers include City Market, Crown Center, Country Club Plaza, Independence Center, Legends Outlets Kansas City, Oak Park Mall, Ward Parkway Center, and Zona Rosa.

Cultural attractions include the American Jazz Museum, the Kansas City Symphony, Kansas City Union Station, the National World War I Museum, the Nelson-Atkins Museum of Art, the Kemper Museum of Contemporary Art, Kauffman Center for the Performing Arts, the National Agricultural Center and Hall of Fame, Arabia Steamboat Museum, Uptown Theater, Midland Theatre, the Kansas City Zoo, Swope Park (featuring Starlight Theater), Sandstone Amphitheater, the Kansas City Renaissance Festival, Worlds of Fun, Oceans of Fun, and several casinos. Major league sports franchises include the NFL's Kansas City Chiefs, the MLB's Kansas City Royals, and the MLS's Sporting Kansas City. The Kansas Speedway is owned by NASCAR.

Historic features include these: the confluence of the eastern endpoints of the California, Santa Fe, and Oregon Trails in Independence; the Harry S. Truman Historic District; and the neighborhoods of Westport, 18th and Vine, and Pendleton Heights. Historic cultural origins include KC styles of jazz, vaudeville theater, barbecue, and steak.